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肠杆菌病Colibacillosis inCalves Preparedby:Dr.Terry Hunt病因/发病机理CausePathogenesis•大肠杆菌K99Escherichia coli-pili K99•内毒素引起小肠液体分泌过度Hyper secretionof fluidsin smallintestine causedby endotoxin危险因素Risk Factors•获得初乳抗体失败Failure ofPassive Transferof AntibodiesColostrum•环境中细菌数量过高Build叩of bacteriain environment•通过脐带或口感染Can entercalf orallyor throughnavel临床症状Clinical Findings•产后四天出现•水样腹泻•脱水、低温•酸中毒•虚弱•死亡Seen mostcommonly incalves under4days ofage Profusewatery dianhea Dehydrationand hypothermiaAcidosis WeaknessDeath尸解诊断Post MortemDiagnosis•利用间接免疫荧光反应,在牛粪和空肠/回肠中发现K99Feces orileum/jejunum-look forK99pili usingindirect immunoflourescence鉴别诊断Differential Diagnosis•沙门氏菌Neonatal Salmonellosis•轮状病毒Rotavirus CoronaVirus•冠状病毒后遗症•败血症•虹膜炎眼前房积脓Sequelae•脓毒性关节炎Septicemia•脑膜炎Iritis,hypopyon•肺炎Septic arthritisMeningitis Pneumonia治疗Treatment纠正脱水和酸中毒Treatment isbased oncorrection ofdehydration andacidosis Dehydration皮肤皱折和眼球凹陷来确定Determined byskin tentingand sunkeneyeballs•体重X%脱水比例=补充的液体量L Bodyweight*°/o dehydration=litres offluids requiredAcidosis-依据敏感性/警觉性确定Determined bythe alertnessof calf•补充等渗溶液Add toisotonic solutions•碳酸氢钠13gm/L13gm ofNa bicarbonatein alitre offluid
1.3%不能吸吮者Depressed calvesthat donot suckle•静注液体加碳酸盐IV fluidsplus bicarbonate细心护理病牛Nursing calvesmildly affectedcalves•多次口服电解液Oral electrolytesby multiplefeeding•若喂牛奶,用非碳酸盐类电解液If fedmilk,use non-bicarbonate electrolytes抗菌药Antimicrobials•仅对细菌性腹泻有效Only effectiveagainst bacterialscours Use•全身使用光谱抗生素broad-spectrum antibioticssystemically•连续口服抗生素时间仅为3天Only useoral antibioticsfor3days预防PreventionControl•出生后2小时内喂初乳Colostrum withinfirst2hours ofbirth•第一次12小时内体重的10%10%of BodyWeight in1st12hours•高质量的初乳IgG为1500mg/dl Highquality colostrum:1500mg/dl ofIgG.使用粉乳井Use Clostromctcr•环境卫生Environmental Hygiene•单个犊牛圈Individual calfhutches•隔离和治疗病牛Isolate andtreat sickcalves•怀孕后期用疫苗免疫接种Vaccinate cowsin latepregnancy topass immunityin colostrum。